She has previously dismissed talk of 'enhancing' her matinee idol looks.
But Meg Ryan, seemed to have discovered the fountain of youth after she unveiled a distinctly different look at the Tony Awards in New York on Sunday.
Indeed, there was much speculation about her spectacular lips, which some online critics likened to Batman villain the Joker's as she stunned at the glittering showbusiness event.
Ageless: Meg Ryan seemed to have discovered the fountain of youth after she unveiled a distinctly different look at the Tony Awards in New York on Sunday
Times are a changing: Meg seen on R in 2002, nearly 14 years ago
Her fans certainly seemed to find her appearance interesting, with her face quickly becoming the number one trending topic on Twitter.
A user named Ken Levine wrote: 'Who besides me let out an audible gasp in horror when they saw Meg Ryan on the Tony Awards?'
While Champagne Fodue mused: 'Meg Ryan and Madonna have the same plastic surgeon'.
Adamant: While her occasionally puffy face and inflated lips have led to speculation, she has always steadfastedly refused to confirm or deny going under the knife.
Mean meme: One of the Twitter responses to Meg's appearance
Trending topic: Meg even eclipsed tweets about the mass shooting at a Florida gay club
Meg even eclipsed tweets about the mass shooting at a Florida gay club - to the outrage of many.
A user named Detroit_D wrote: 'Meg Ryan's face is a major trending topic the day after a major mass shooting in Orlando. It is truly a sad state of affairs for our nation.'
And Stephanie MacCromack said: 'Can someone explain to me how 50 ppl were senselessly killed and the #1 trending topic is Meg Ryan at the Tony's? Wtf world do we live in?'
Meg has in the past admitted she gets annoyed by the constant plastic surgery speculation and insisted she actually loves the ageing process.
Last year she told Porter Magazine: 'We get stuck in these conversations about looks and hair color and our roots.
'It's interesting and funny for five minutes. But it's not that interesting.'
America's darling: Meg's stunning looks have seen her snare a cavalcade of desirable men, including singer John Mellencamp and Russell Crowe
While her occasionally puffy face and inflated lips have led to speculation, Meg has always steadfastedly refused to confirm or deny going under the knife.
She said: 'I love my age. I love my life right now. I love the person I've become, the one I've evolved into.
'In my life I've been scrappy as hell, but I feel easy with things now. I think that comes with age.'
Meg's stunning looks have seen her snare a cavalcade of desirable men, including singer John Mellencamp and Russell Crowe.
She was also married to her Inner Space co-star Dennis Quaid until 2001.
2016 TONY AWARD WINNERS
BEST MUSICAL
Hamilton - WINNER
Shuffle Along
Waitress
School of Rock - The Musical
Bright Star
BEST PLAY
Eclipsed
The Father
The Humans - WINNER
King Charles III
BEST REVIVAL OF A PLAY
The Crucible
A View From the Bridge - WINNER
Blackbird
Long Day's Journey Into Night
Noises Off
BEST REVIVAL OF A MUSICAL
The Color Purple - WINNER
Fiddler on the Roof
She Loves Me
Spring Awakening
Dames at Sea
BEST BOOK OF A MUSICAL
Bright Star - Steve Martin
Hamilton - Lin-Manuel Miranda - WINNER
School of Rock - The Musical - Julian Fellowes
Shuffle Along - George C. Wolfe
BEST ORIGINAL SCORE (MUSIC AND/OR LYRICS)
Steve Martin and Edie Brickell - Bright Star
Lin-Manuel Miranda - Hamilton - WINNER
Andrew Lloyd Webber and Glenn Slater - School of Rock - The Musical
Sara Bareilles - Waitress
BEST PERFORMANCE BY AN ACTOR IN A LEADING ROLE IN A PLAY
Gabriel Byrne in Long Day's Journey Into Night
Jeff Daniels in Blackbird
Mark Strong in A View From the Bridge
Frank Langella in The Father - WINNER
Tim Pigott-Smith in King Charles III
BEST PERFORMANCE BY AN ACTRESS IN A LEADING ROLE IN A PLAY
Jessica Lange in Long Day's Journey Into Night - WINNER
Michelle Williams in Blackbird
Laurie Metcalf in Misery
Sophie Okonedo in The Crucible
Lupita Nyong'o in Eclipsed
BEST PERFORMANCE BY AN ACTOR IN A LEADING ROLE IN A MUSICAL
Lin-Manuel Miranda in Hamilton
Leslie Odom Jr. in Hamilton - WINNER
Alex Brightman in School of Rock
Danny Burstein in Fiddler on the Roof
Zachary Levi in She Loves Me
BEST PERFORMANCE BY AN ACTRESS IN A LEADING ROLE IN A MUSICAL
Phillipa Soo in Hamilton
Cynthia Erivo in The Color Purple - WINNER
Jessie Mueller in Waitress
Laura Benanti in She Loves Me
Carmen Cusack in Bright Star
BEST PERFORMANCE BY AN ACTOR IN A FEATURED ROLE IN A PLAY
Reed Birney in The Humans - WINNER
Bill Camp in Arthur Miller's The Crucible
David Furr in Noises Off
Richard Goulding in King Charles III
Michael Shannon in Long Day's Journey Into Night
BEST PERFORMANCE BY AN ACTRESS IN A FEATURED ROLE IN A PLAY
Pascale Armand in Eclipsed
Megan Hilty in Noises Off
Jayne Houdyshell in The Humans - WINNER
Andrea Martin in Noises Off
Saycon Sengbloh in Eclipsed
BEST PERFORMANCE BY AN ACTOR IN A FEATURED ROLE IN A MUSICAL
Daveed Diggs in Hamilton - WINNER
Brandon Victor Dixon in Shuffle Along
Christopher Fitzgerald in Waitress
Jonathan Groff in Hamilton
Christopher Jackson in Hamilton
BEST PERFORMANCE BY AN ACTRESS IN A FEATURED ROLE IN A MUSICAL
Danielle Brooks in The Color Purple
Renée Elise Goldsberry in Hamilton - WINNER
Jane Krakowski in She Loves Me
Jennifer Simard in Disaster! The Musical
Adrienne Warren in Shuffle Along
BEST CHOREOGRAPHY
Andy Blankenbuehler, Hamilton - WINNER
Savion Glover, Shuffle Along
Hofesh Shechter, Fiddler on the Roof
Randy Skinner, Dames at Sea
Sergio Trujillo, On Your Feet
BEST ORCHESTRATIONS
August Eriksmoen, Bright Star
Larry Hochman, She Loves Me
Alex Lacamoire, Hamilton - WINNER
Daryl Waters, Shuffle Along
BEST SCENIC DESIGN OF A PLAY
Beowulf Boritt, Thérèse Raquin
Christopher Oram, Hughie
Jan Versweyveld, A View from the Bridge
David Zinn, The Humans - WINNER
COSTUME DESIGN OF A MUSICAL
Gregg Barnes, Tuck Everlasting
Jeff Mahshie, She Loves Me
Ann Roth, Shuffle Along
Paul Tazewell, Hamilton - WINNER
BEST COSTUME DESIGN OF A PLAY
Jane Greenwood, Long Day's Journey Into Night
Michael Krass, Noises Off
Clint Ramos, Eclipsed - WINNER
Tom Scutt, King Charles III
BEST LIGHTING DESIGN OF A MUSICAL
Howell Binkley, Hamilton - WINNER
Jules Fisher and Peggy Eisenhauer, Shuffle Along
Ben Stanton, Spring Awakening
Justin Townsend, American Psycho
BEST LIGHTING DESIGN OF A PLAY
Natasha Katz, Long Day's Journey Into Night - WINNER
Justin Townsend, The Humans
Jan Versweyveld, The Crucible
Jan Versweyveld, A View from the Bridge
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